Holtzman Lab is Published in JI!

The left photo is PAS-hematoxylin staining of a section of normal lung, and the right is from a section of lung after the development of progressive lung disease long after respiratory viral infection (starting as soon as 5 days and here peaking at 7 weeks after initial infection).

In these photos, we are also using image analysis to red colorize the mucus/PAS+ material to allow for improved visualization and quantitation.

In addition, you can see the increased cellularity/hematoxylin/blue staining as a sign of inflammation and stem cell proliferation.

End result is excessive airway inflammation and mucus production and so morbidity and mortality.

Check out the published article here.

Photo Credit: Kangyun Wu

Jennifer Alexander-Brett, MD, PhD Saves Pregnant Mother of 2 From COVID-19!

Jennifer Alexander-Brett, MD, PhD saved the life of a pregnant mother of 2 from COVID-19. Check out the rest of this inspiring story here: http://archive.is/dTLfI

Adam Anderson, MD Receives BJC Grant!

Adam Anderson, MD has received a grant from BJC. The title of the grant is: Development of a Washington University/Barnes-Jewish Hospital Sarcoidosis Center of Excellence Registry. The award period is from July 1, 2020 to June 30, 2021.

Dr. Michael J. Holtzman Receives TTDA Award!

Dr. Michael J. Holtzman received a Technology/Therapeutic Development Award (TTDA) from the Department of Defense for “Preclinical Development of a New Kinase Inhibitor for COPD”. The 3-year award for $3,928,669 will focus on progressive post-viral lung disease, especially relevant to current public health problems with respiratory viral infections including Covid-19, influenza, and other common pathogens. The funding will provide for final preclinical development of a lead compound to achieve approval for clinical trials in human patients.

Andrew Michelson, MD Receives COVID-19 Grant!

Andrew Michelson, MD, Assistant Professor in Pulmonary and Critical Care Medicine, has received a COVID-19 grant. The project period will be 07/01/20 to 02/28/21. The title of his grant is: “Artificial Intelligence for the Real-time Prediction of Respiratory Deterioration in SARS-COV2 Infected Patients: A Clinical Triage Tool.”

Jennifer Alexander-Brett, MD, PhD receives R01 from NHLBI!

Jennifer Alexander-Brett, MD, PhD has received a R01 from the NHLBI starting July 1, 2020. Her project title is “Non-Classical Cytokine Secretion in Chronic Airway Disease.”

Health Care Hero, Dr. Patrick Lyons!

Dr. Patrick Lyons, Instructor of Medicine in The Division of Pulmonary and Critical Care Medicine has been attending in the COVID ICUs and leading the clinical operations on the ground in these units since March 16.

The clinical work has involved admitting critically ill patients with diagnosed or suspected COVID-19, performing urgent critical care procedures like intubations, central lines, and chest tubes, rounding on these patients with the team of fellows and APPs, and staying in contact with patients’ families via telephone.

The administrative work involves creating and updating our handbook of procedures and protocols and working with the nurses and other clinicians to adapt to the “usual” way of doing things to the pandemic situation (for example, instituting a morning/evening huddle for the entire team, since many nurses and physicians have been pulled from different areas and don’t know each other well).

Dr. Lyons has seen 12-18 patients per day. He has epitomized dedication to patient care and “all hands-on deck” mentality; working the most ICU shifts out of all intensivists, while being separated from his family. He is very deserving of recognition for his efforts.

Health Care Hero, Dr. Colleen McEvoy!

Dr. Colleen McEvoy, Assistant Professor of Medicine in Pulmonary and Critical Care Medicine has provided extraordinary service to critically ill patients. Dr. McEvoy has been maintaining the scheduling and logistical coordination.

She is the co-leader of the COVID Critical Care task force. Since COVID-19 is a new disease, they needed to very quickly provide information on management to the teams working on “the ground”. Dr. McEvoy and her staff collaborated with numerous specialties to develop COVID management guidelines based on the experience with other diseases, supplemented with clinical experience of COVID-19 at BJH and from colleagues around the country and globe, and incorporated the rapidly growing published scientific literature on COVID-19.

She has worked with WUSTL Anesthesia and Neurology Critical Care colleagues to develop a surge plan staffing model. She was responsible for staffing the COVID ICUs. In order to keep the teams including attendings, fellows and APP up to date with COVID, Dr. McEvoy has been coordinating weekly Zoom COVID updates. She has also been working with Wash U Peer Support Group and Psychiatry to develop wellness resources for providers during this high intensity time.


Laneshia K. Tague, MD, MSCI receives AFMR Award!

Laneshia K. Tague, MD, MSCI has received the American Federation for Medical Research (AFMR) Junior Physician-Investigator Award. This award was created to honor young AFMR investigators whose research projects complement an overall program of research, teaching and clinical medicine. Candidates must have submitted an abstract to one of the AFMR Regional Meetings. Applications were judged on both the quality of the abstract submitted and their career accomplishments. Dr. Tague will receive a Certificate of Excellence and a $1,250 honorarium at the meeting.

Hrishikesh Kulkarni, MD, MSCI receives Discovery Award!

Dr. Hrishikesh Kulkarni (Principal Investigator) received a Discovery Award (Peer Reviewed Medical Research Program) from the Department of Defense for the period of 7/1/20 – 6/30/22. Along with Dr. Andrew Gelman (Cardiothoracic Surgery), they will study how activators of the complement cascade (such as pentraxin 3) increase the risk of acute lung injury (primary graft dysfunction) after lung transplantation with the aim of devising therapies to block its effect.

Hrish Kulkarni, MD, MSCI Receives CDI Grant

Dr. Kulkarni has received an award from the Children’s Discovery Institute. His grant will be for $300,000 for 5 years. The title is “Harnessing the complement system to mitigate acute lung injury.”

103 Lung Transplant Achievement is History in the Making!

The Lung Transplant Program at Washington University School of Medicine is celebrating its success in completing 103 lung transplants in 2019! Read more here: https://surgery.wustl.edu/103-lung-transplant-achievement-is-history-in-the-making/

Michael Hughes, PhD Receives R01 from NIH

Michael Hughes, PhD has received an R01 AR075017-01A1 from the NIH. The title is: “A Systematic Analysis of RNA Editing in Skeletal Muscle.” The aims of this study are to determine whether RNA editing influences skeletal muscle specialization using in silico approaches; testing whether muscle-specific trans factors regulate RNA editing by using in vitro cell culture; and testing whether RNA editing of Nebulin regulates sarcomere function using in vivo models.

Congrats to Dr. Derek Byers for getting the Bee Award!

Dr. Derek Byers was awarded the Bee Award today for going above and beyond for his patients. Congrats to Dr. Byers!

Hrish Kulkarni, MD, MSCI Receives K08 from NIH

Hrish Kulkarni, MD, MSCI has received a K08 from the NIH. His project title is C3 Mitigates Epithelial Injury in Pneumonia. The project period will be from 09/01/2019 to 08/31/2024.

Dr. Andrew Michelson Attends NCATS Un-Meeting

Andrew Michelson, MD, WU Pulmonary and Critical Care fellow, was recently awarded a travel stipend to attend the June 1 “Un-Meeting: Machine Learning and Artificial Intelligence Applications in Translational Science” by the Center for Leading Innovation and Collaboration (CLIC) at the University of Rochester Medical Center. CLIC, which serves as the coordinating center for the National Center for Advancing Translational Sciences (NCATS), hosted the meeting and provided for one travel stipend award for each CTSA program hub.

Over 95 researchers, academic faculty, informaticians and clinicians from across the country attended the day-long event, representing 45 CTSA program hubs in 27 states. “This was a unique opportunity to collaborate with several other institutions and a professionally diverse group of participants,” commented Michelson. “I’m so pleased I had this opportunity and look forward to potential future collaborations with my fellow participants.”

Dr. Laneshia Tague Receives KL2 Award

Dr. Laneshia Tague has received a KL2 award with a July 1st, 2019 appointment start. The grant title is “Pharmacogenetic-based Mycophenolate Dosing to Improve Lung Transplant Outcomes”.

Congratulations to the 2019 SPIRiT Awardee Dr. Hrishikesh Kulkarni!

Hrishikesh Kulkarni, MD, MSCI, with his collaborating PI, has been awarded a $50,000/one year award for his research project through the SPIRiTfunding program. The SPIRiT (Sharing Partnership for Innovative Research in Translation) consortium is a partnership between Clinical and Translational Science Award (CTSA) sites including: Johns Hopkins University, University of Chicago, University of Pennsylvania, University of Pittsburgh, Washington University in St. Louis, and Yale University. SPIRiT awardees must submit projects where they collaborate with an investigator from a participating CTSA institution.

Dr. Pat Lyons Awarded an AnnalsATS Editorial Fellowship

Congratulations to Dr. Pat Lyons for being awarded an AnnalsATS Editorial Fellowship. Fellows serve 1-3 year appointments and receive mentored guidance in all aspects of manuscript evaluation and publication. More information can be found at https://doi.org/10.1513/AnnalsATS.201812-902ED.

Steven Brody, MD receives R01 from NHLBI

In March 2019, Steven Brody, MD has received a new R01 from the National Heart, Lung, and Blood Institute. His project title is: “Cellular and Molecular Features of Gene Mutations in Primary Ciliary Dyskinesia.”

Michael J. Holtzman, MD receives an Outstanding Investigator Award from NHLBI

Michael J. Holtzman, MD received an Outstanding Investigator Award entitled “Defining and Controlling Airway Disease” from the National Institutes of Health, National Heart, Lung, and Blood Institute.  This Project aims at reprogramming epithelial stem cells in the lung to understand and prevent respiratory airway diseases such as asthma and chronic obstructive pulmonary disease (COPD).  The award will provide $6,608,000 over 7 years for Dr. Holtzman’s research activities.  

Colleen McEvoy, MD receives award from The Foundation for Barnes-Jewish Hospital

Colleen McEvoy, MD an Assistant Professor in Pulmonary and Critical Care Medicine has received an award from The Foundation for Barnes-Jewish Hospital to create a single-site clinical data registry of patients in the BMT and Oncology Intensive Care Unit.

Hrishikesh Kulkarni, MD, MSCI, receives Biomedical Research Award from American Lung Association

Hrishikesh Kulkarni, MD, MSCI, an Instructor of Medicine in Pulmonary and Critical Care Medicine has received a Biomedical Research Award from the American Lung Association to investigate the role of complement protein C3 in severe pneumonia.

Kayla Berry is awarded an NIH/NHLBI F30 Predoc Fellowship

Kayla Berry, MSTP Student in Dr. Brett’s lab has been awarded a 3 year MD/PhD F30 Predoc Fellowship from the NIH for her project titled “Molecular Mechanism of TMEM16A Surface Stabilization by CLCA1.”

Kayla Berry is selected for an oral presentation in Chicago for ASCI/AAP

Kayla Berry from Tom Brett’s lab was selected as one of only two trainee presentations for the ASCI/AAP meeting. MSTP is only sponsoring 19 students to travel to the ASCI/AAP meeting in Chicago. Kayla was selected out of a competitive group of trainees at this meeting.