The following list represents open investigator-initiated and sponsored clinical trials available through Pulmonary and Critical Care Medicine, Adult Thoracic Surgery and Adult Lung Transplantation.
Resistant Airway Obstruction in Children
Mario Castro, MD, MPH. WU-201411133
Steroids in Eosinophil Negative Asthma
Mario Castro, MD, MPH. WU-201404134
Efficacy and Safety of Beta-adrenoceptor Inverse Agonist and Biased Ligand, Nadalol, In Smoking Cessation of Patients with Chronic Cough with or without Airflow Obstruction
Mario Castro, MD, MPH. WU-201308077
A Phase 2a, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Parallel Group Study of JNJ-38518168 in Symptomatic Adult Subjects with Uncontrolled, Persistent Asthma
Mario Castro, MD, MPH. WU-201306011
A Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of Brodalumab in Subjects With Inadequately Controlled Asthma and High Bronchodilator Reversibility
Mario Castro, MD, MPH. WU-201304121
Smoking Asthmatics Cohort Study
Mario Castro, MD, MPH. WU-201211136
Evaluation of the Washington University Center for Smoking Cessation
Mario Castro, MD, MPH. WU-201207112
Severe Asthma Research Program (SARP III)
Mario Castro, MD, MPH. WU-201206102
A Prospective Observational Study of Biopredictors of Bronchial Thermoplasty Response in Patients with Severe Refractory Asthma (BTR Study)
Mario Castro, MD, MPH. WU-201106118
A 30-34 week, treatment randomized, double -blind, placebo-controlled study of the effects of cKit inhibition by imatinib in patients with severe refractory asthma (KIA)
Mario Castro, MD, MPH. WU-201102303
Fiberoptic Bronchoscopy and Bronchial Biopsy in Asthma Patients and Normal and Disease Controls
Mario Castro, MD, MPH. WU-201012967
Best African American Response to Asthma Drugs
Mario Castro, MD, MPH /Leonard Bacharier,MD. WU-201310066
Nadolol in Mild Asthma
Mario Castro, MD, MPH /Cajal Sumino, MD. WU-201210088
Asthma Symptom Based of Inhaled Steroid Therapy in African American children
Mario Castro, MD, MPH /Cajal Sumino, MD. WU-201410095
A randomized, double-blind, placebo-controlled, parallel group study to assess the efficacy, safety, and tolerability of PF-03715455 administered twice daily by inhalation for 12 weeks in subjects with persistent moderate to severe asthma who remain uncontrolled despite treatment with inhaled corticosteroids (ICS) and long-acting beta-2 agonists (LABA)
Mario Castro, MD, MPH. WU-201411012
A study of inhaled NITROsyl in subjects with pulmonary arterial hypertension and pulmonary hypertension secondary to idiopathic pulmonary fibrosis.
Murali Chakinala. WU- 201111037
A Phase 3b study of macitentan in patients with pulmonary arterial hypertension to psychometrically validate the PAH-SYMPACT instrument.
Murali Chakinala. WU-201307043
A phase IIIb study of riociguat in patients with pulmonary arterial hypertension who demonstrate an insufficient response to phosphodiesterase-5 inhibitors.
Murali Chakinala. WU-201402110
A study of the efficacy and safety of bardoxolone methyl in patients with pulmonary arterial hypertension.
Murali Chakinala. WU- 201402087
A study of an ASK1-inhibitor in patients with pulmonary arterial hypertension.
Murali Chakinala. WU- 201409085
A phase II study to evaluate the effects of up to 12 weeks of pazopanib dosing on bleeding in patients with hereditary hemorrhagic telangiectasia.
Murali Chakinala. WU-201411030
Extracorporeal photopheresis for the management of progressive bronchiolitis obliterans syndrome in Medicare-eligible recipients of lung allografts
Ramsey Hachem, MD
A pilot randomized controlled trial of de novo Belatacept-based immunosuppression in lung transplantation.
Ramsey Hachem, MD
The Use of Lactobacillus Rhamnosus GG to Reduce Colonization With Antimicrobial-Resistant Bacteria in High-Risk Patients.
Marin Kollef, MD. WU-201106182
Impact of Aggressive Empiric Antibiotic Therapy and Duration of Therapy on the Emergence of Antimicrobial Resistance during the Treatment of Hospitalized Subjects with Pneumonia Requiring Mechanical Ventilation
Marin Kollef, MD. WU- 201209101
A Randomized Double-Blind, Placebo-Controlled, Parallel Group, Phase 2 Study of Aerosolized Amikacin and Fosfomycin Delivered via the Investigational eFlow® Inline System in Mechanically Ventilated Patients with Gram-negative Bacterial Pneumonia
Marin Kollef, MD. WU-20131209
BI1199.214: Safety and efficacy of oral nintedanib in patients with Systemic Sclerosis associated Interstitial Lung Disease.
Tonya Russell, MD. WU-201511005
Post-FDA-Approval Clinical Trial Evaluating Bronchial Thermoplasty in Severe Persistent Asthma
Adrian Shifren, MD. WU-201104349
A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study to Assess the Efficacy and Safety of Simtuzumab (GS-6624) in Subjects With Idiopathic Pulmonary Fibrosis (IPF) (RAINIER)
Adrian Shifren, MD
A Safety and Efficacy Trial Evaluating the Use of Betrixaban for the Prevention of Deep Vein Thrombosis and Pulmonary Embolism
Roger D. Yusen, MD, MPH