Jeff Haspel, MD, PhD

Research Interests

The overall focus of my lab is to understand the impact of circadian rhythms in the critically ill, especially for those patients with respiratory failure due to pneumonia or generalized sepsis. Circadian rhythms are daily variations in biological function that are critical for health. In the ICU environment circadian rhythms are routinely overlooked on the assumption that they are absent in critically ill patients. However our observations in mouse models suggest that circadian rhythms may in fact be prevalent at the molecular level in systemically ill organisms. To this end we are pursuing several projects to understand the purpose of circadian regulation during critical illness. First we are analyzing how inflammation alters circadian rhythms in macroautophagy, a catabolic process responsible for digesting unwanted cellular components in lysosomes. In a separate project we are analyzing the biological ramifications of circadian rhythm disruption in animal models of viral pneumonia and bacterial sepsis. Finally we are examining how chronological age interacts with circadian rhythms to influence the severity of viral pneumonia and chronic lung remodeling after resolution of the acute infection. We hope this work will improve our understanding of time as a biological variable in sepsis and respiratory failure, and also engender new thinking relevant to managing patients in the ICU.

Education and Training

  • 1990-1994 Binghamton University, Binghamton, New York
  • 1994-2003 NYU School of Medicine, Medical Scientist Training Program, New York, New York
  • 2003-2006 Residency, Mount Sinai School of Medicine
  • 2006-2010 Fellowship, Harvard Combined Program in Pulmonary and Critical Care Medicine

Honors and Awards

  • 1993 Barry M. Goldwater Scholar in Science, Barry M. Goldwater Foundation
  • 1993 Phi Beta Kappa Inductee, Phi Beta Kappa
  • 1994 Suma Cum Laude, Binghamton University
  • 1994 Golden Key National Honor Society Inductee, Golden Key National Honor Society
  • 2011 Parker B. Francis Scientific Opportunity Award

Publications

View Jeff Haspel’s research publications on PubMed ยป