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Research Interests
I am interested in the role of innate immune cells in lung injury and repair. My research has involved the presence and activity of matrix metalloproteinases in mouse models and human lung disease. I am currently engaged in studies evaluating CCR2+monocytes in fibrosing lung diseases and the potential role of PET imaging to follow cellular activity.
I am also heavily involved in clinical trials of all phases in collaboration with the Cystic Fibrosis Therapeutics Development Network. We have been fortunate to be able to partner with industry sponsors and enroll many local patients in pivotal phase II and phase III clinical trials that have dramatically altered the outcomes of our patients.
Education and Training
- 1990 Loyola College, Baltimore, Maryland
- 1994 Hahnemann University School of Medicine, Philadelphia, PA
- 1994-1997 Residency, Internal Medicine, University Hospitals of Cleveland, Ohio
- 1997-1998 Chief Resident, University Hospitals of Cleveland, Ohio
- 1998-2001 Fellow, Washington University School of Medicine, St. Louis, Missouri
- 2001-2004 Clinical Instructor/Post-Doctoral Research Scholar, Washington University School of Medicine, St. Louis, MO
- 2005-2006 Instructor in Medicine, Washington University School of Medicine, St. Louis, Missouri
- 2006-2017 Assistant Professor of Medicine, Washington University School of Medicine, St. Louis, MO
- 2017-2023 Associate Professor of Medicine, Washington University School of Medicine, St. Louis, MO
- 2023-present Professor of Medicine, Washington University School of Medicine, St. Louis, MO
- 2002-present Associate Director, Adult Cystic Fibrosis Program, Washington University School of Medicine, St. Louis, Missouri
- 2006-present Director Adult Ciliary Dyskinesia Program, Washington University School of Medicine, St. Louis, Missouri
- 2012-present Medical Director, Pulmonary Function Laboratory, Washington University School of Medicine, St. Louis, Missouri