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Viral persistence, inflammation, and macrophage apoptosis in newly-generated chemokine CCL5-null mice. The photomicrographs represent serial lung sections from post-inoculation day 9 that were subjected to immunostaining with anti-viral (SeV) and anti-macrophage (Mac3 )antibodies and to the TUNEL reaction for detecting apoptosis. The results established this system as one that is critical for host defense.
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Introduction The Division of Pulmonary and Critical Care Medicine at Washington University School of Medicine trains pulmonary physicians, physician-scientists and pre- and postdoctoral basic scientists in physiology, cell biology, and molecular biology of the respiratory system. The Division combines a vigorous basic science core composed of established cell and molecular biologists and physiologists with an active clinical service and clinical investigative group at Barnes-Jewish Hospital South Campus and Barnes-Jewish Hospital North Campus at the Washington University School of Medicine Medical Center and the John Cochran Veterans Affairs Medical Center.
The Division enjoys extensive support from the National Institutes of Health (NIH) in the form of numerous individual research grants, program project and SCOR grants, and an institutional training grant that supports graduate students and Ph.D. and M.D. postdoctoral fellows. Divisional faculty serve on the NIH Study Sections and the American Lung Association grant review committees, as well as numerous editorial boards. The faculty also have chaired national and international scientific meetings related to clinical and basic science investigation. Pulmonary Medicine at Barnes-Jewish Hospital is consistently rated among the top six pulmonary programs in the United States. http://health.usnews.com/usnews/health/best-hospitals/search.php?spec=ihqpulm&
The clinical facilities of the hospital system, together with more than 14,000 square feet of research space and a stimulating intellectual environment, provide an ideal setting in which to obtain training in diagnosis and treatment of patients with lung disease and in basic mechanisms of lung function.
The Division is responsible for a full spectrum of patients with pulmonary disorders. Specific centers of excellence now include asthma; cystic fibrosis; lung transplantation; living related lobar donors; critical care medicine; industrial medicine; long-term ventilation; pulmonary vascular disease; pulmonary emphysema and lung volume reduction surgery; pulmonary surfactant abnormalities; chronic obstructive pulmonary disease and pulmonary rehabilitation; lung cancer; pulmonary arteriovenous malformations and noninvasive ventilation; and sleep disorders.
Division of Pulmonary and Critical Care Medicine
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