Michael J. Walter, M.D.

Assistant Professor of Medicine

CONTACT INFORMATION

Washington University School of Medicine
660 S. Euclid Avenue, Campus Box 8052
St. Louis, MO 63110
(314) 7747-2955 (phone)
(314) 362-8987 (fax)
walterm@msnotes.wustl.edu

EDUCATION/TRAINING

St. Louis University, St. Louis, MO, B.A. 1982-1986 Chemistry
St. Louis Univ. School of Medicine, St. Louis, MO, M.D. 1986-1990 Medicine
Mount Sinai Medical Center, New York, NY, Internship 1990-1991 Internal Medicine
Mount Sinai Medical Center, New York, NY, Residency 1991-1993 Internal Medicine
Washington Univ. School of Medicine, St. Louis, MO, Fellowship 1993-1999 Pulmonary Medicine

POSITIONS

1999-2000 Instructor of Medicine, Washington university School of Medicine, St. Louis, MO
2000-Present Assistant Professor of Medicine, Washington university School of Medicine, St. Louis, MO

HONORS

1990, Alpha Omega Alpha Medical Honor Society
1996, Gosselin Pediatric Asthma Fellowship Award
1998, NIH, NHLBI Mentored Clinical Scientist Development Award
1999, American Lung Association Research Grant
1999, American Lung Association Edward Livingston Trudeau Scholar
2000, Fellow, American College of Chest Physicians
2001, Editorial Board, Am. J. Respir. Cell Mol. Biol.

PUBLICATIONS

1. Kalb T., Walter M., Mayer L., Acarli K., Fukuzawa K., Schwartz M., Miller C. Intra-allograft Production and Systemic Release of Tumor Necrosis Factor-Alpha. Detection Upon Reperfusion. Transplantation Proceedings 25:1817-1818, 1993.

2. Walter, M.J., Look, D.C., Tidwell, R.M., Roswit, W.T., Holtzman, M.J. Targeted Inhibition of Interferon-g-dependent ICAM-1 Expression Using Dominant-negative Stat1. Journal of Biologic Chemistry, 272:45, 28582-28589, 1997.

3. Holtzman, M.J., Look, D.C., Sampath, D., Castro, M., Koga, T., Walter, M.J. Control of Epithelial Immune-Response Genes and Implications for Airway Immunity and Inflammation. Proceedings of the Association of American Physicians, 110:1, 1-11, 1998.

4. Look, D.C., Roswit W.T., Frick A.G., Gris-Alevy Y., Dickhaus D.M., Walter M.J., Holtzman, M.J. Direct Suppression of Stat1 Function during Adenoviral Infection. Immunity 9:871-880, 1998.

5. Castro, M., Chaplin, D., Walter, M.J., Holtzman, M.J. Could asthma worsen by stimulating the T helper type 1 (Th1) immune response? American Journal of Respiratory Cell and Molecular Biology, 22:2, 143-146, 2000.

6. Holtzman, M.J., Castro, M., Look, D.C., O'Sullivan, M., Walter, M.J. Regulation of epithelial-leukocyte interactions and epithelial immune-response genes. In Asthma and Rhinitis (W. Busse and S. Holgate, editors) Blackwell Scientific, Cambridge, MA, 784-800, 2000.

7. Walter, M.J., Kajiwara, N., Karanja, P., Castro, M., Holtzman, M.J. Interleukin 12 p40 Production by Barrier Epithelial Cells during Airway Inflammation. Journal of Experimental Medicine, 193:3, 339-351, 2001.

8. Look, D.C., Walter, M.J., Williamson, M.R., Pang, L., You, Y., Sreshta, J.N., Johnson, J.E., Zander, D.S., Brody, S.L. Effects of Paramyxoviral Infection on Airway Epithelial Cell Foxj1 Expression, Ciliogenesis, and Mucociliary Function. American Journal of Pathology, 159:6, 2055-2069, 2001

9. Holtzman, M.J., Morton, J.D., Shornick, L.P., Tyner, J.W., O'Sullivan, M.P., Antoa, A., Castro, M., Walter, M.J. Immunity, inflammation,and Remodeling in the Airway Epithelial Barrier: Epithelial-Viral-Allergic Paradigm. Physiologic Review, 82:19-46, 2002

10. Walter, M.J., Morton, J.E., Kajiwara, N., Agapov, E. Holtzman, M.J. Viral Induction of a Chronic Asthma Phenotype and Genetic Segregation from the Acute Response. Submitted.

11. Walter, M.J., Holtzman, M.J. Epithelial Production of IL-12 p80 During Viral Infection and Asthma Supports an Altered Paradigm for Airway Inflammation. In Lung Biology in Health and Disease (N. Eissa and D. Huston, editors) Marcel Dekker, submitted, 2002

RESEARCH SUPPORT

2 P50 HL56419-08
09/01/01 – 08/31/06
10% effort
NIH/NHLBI
(Core D)
SCOR “Mechanisms of Airway Inflammation and Remodeling, Mouse Genetics Core D”
The major objective of this core is to provide a centralized service oriented facility that will insure the capacity of each participating project lab to produce transgenic and gene-disrupted mice.

1 RO1 HL71947-01 (Walter, Michael PI)
01/01/03 – 12/31/06
60% effort
NIH/NHLBI
IL-12 p80 Mediated Airway Inflammation
Role: Principal Investigator
The goals of this project are to define p80-dependent macrophage accumulation following SdV infection and characterize the proteins that mediate this response.

U10 HL74208-01 (Castro, Mario PI)
09/15/03 – 07/31/08
05% effort
NIH/NHLBI
“Asthma Clinical Research Network – Washington University
Role: Co-Investigator
The overall goal of this proposal is to optimize asthma management for the majority of patients with asthma by addressing two clinical issues: 1) What is the best method of asthma self-management when using an asthma action plan and 2) What is the best treatment to prevent as asthma exacerbation during a respiratory tract infection.

Division of Pulmonary and Critical Care Medicine
Department of Medicine
Washington University School of Medicine