Robert M. Senior, M.D.

Professor of Medicine and Cell Biology & Physiology

EDUCATION/TRAINING

Oberlin College, Oberlin, Ohio, A.B. 1957 Chemistry
George Washington University, Washington DC, M.D. 1961 Medicine
Barnes Hospital, St. Louis, MO, Intern/Resident 1961-1963 Internal Medicine
Jewish Hospital, St. Louis, MO, Resident 1963-1964 Internal Medicine
Columbia University, New York, NY, Fellow 1964-1966 Pulmonary Physiology

APPOINTMENTS

United States Army Medical Corps, Walter Reed Army Medical Center, 1966-1969.
Director, Respiratory and Critical Care Division, Jewish Hospital, St. Louis, MO, 1969-1996.
Assistant Professor of Medicine, Washington University School of Medicine, St. Louis, MO, 1969-1973.
Associate Professor of Medicine, Washington University School of Medicine, St. Louis, MO, 1973-1979.
Professor of Medicine, Washington University School of Medicine, St. Louis, MO, 1979-present.
Director, Department of Medicine, The Jewish Hospital of St. Louis, 1989-1990.
Professor of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, 1999-present.

HONORS

American Society for Clinical Investigation, 1979.
Association of American Physicians, 1985.
American Review of Respiratory Disease, Associate Editor, 1985-1988.
American Association for the Advancement of Science, Fellow, 1987.
Moog Professor of Pulmonary Diseases, Washington University School of Medicine, 1988-present.
American Journal of Respiratory Cell and Molecular Biology, Founding Co-Editor, 1988-1993.
Gordon Research Conference on Elastin, Chairman, 1993.
Alton Ochsner Award, American College of Chest Physicians, 1995.
Distinguished Achievement Award, American Thoracic Society, 1998.
Aspen Lung Conference: COPD. Conference Summarizer, 1999.
Alafi Family FoundationÕs ÒPerson of Promise AwardÓ, 2000.
Washington University School of Medicine Alumni Association: Distinguished Service Award, 2001.

PUBLICATIONS

RESEARCH PROJECTS ONGOING OR COMPLETED DURING THE LAST 3 YEARS

"Mechanisms in the remodeling of lung structure"
Project 1: Laminin a chains in lung development and disease.
Agency: NIH-NHLBI (Program Project)
Type: PO1 (HL29594, Years 16-20) Period: September 1, 1998 to August 31, 2003
The goals of this project are to 1)assess the affects of laminin a5 deficiency on lung development, 2) define the regulation of laminin a5, and 3) determine laminin a5 expression in lung injury.
Role: Program Director/Project Leader: R.M. Senior

"Mechanisms in the remodeling of lung structure"
Core A : Administrative Core
Agency: NIH-NHLBI (Program Project)
Type: PO1 (HL29594, Years 16-20) Period: September 1, 1998 to August 31, 2003
Supervision of the administrative functions of the Program Project.
Role: Program Director/Project Leader: R.M. Senior

"92 kDa gelatinase and collagenases in emphysema"
Agency: NIH-NHLBI
Type: RO1 (HL47328, Years 6-10) Period: February 1, 1997 Ð January 31, 2002
The goals of this grant are 1) localize the elastin binding site in 92 kDa gelatinase fibronectin repeats, 2) define the function of 92 kDa gelatinase in inflammatory cells, and 3) determine whether 92 kDa deficiency protects mice from smoke-induced emphysema.
Role: Principal Investigator: R.M. Senior

Pending Grants:
"The Role of Gelatinase B in Terminal Airway Remodeling"
Agency: NIH-NHLBI
Type: RO1 (HL47328, Years 11-15) Period: July 1, 2002 - June 30, 2007
The goals of this grant are 1) to determine whether gelatinase B expression by Clara cells rescues defects in epithelial cell repair in terminal airways associated with gelatinase B deficiency, 2) to define the role of gelatinase B in Clara cell function, and 3) to assess the effects of EMMPRIN on the expression of matrix metalloproteinases by lung cells.
Role: Principal Investigator: R.M. Senior

Division of Pulmonary and Critical Care Medicine
Department of Medicine
Washington University School of Medicine