Michael J. Holtzman, M.D.

Seldin Professor and Director, Pulmonary & Critical Care Medicine

CONTACT INFORMATION

Washington University School of Medicine
660 S. Euclid Avenue, Campus Box 8052
St. Louis, MO 63110
(314) 362-8983 (phone)
(314) 362-8987 (fax)
mholtzma@im.wustl.edu

EDUCATION/TRAINING

-Northwestern University, Evanston, IL B.A. 1971 Biology
-Northwestern University, Chicago, IL M.D. 1975 Medicine
-Duke University, Durham, NC Internship 1976 Internal Medicine
-Duke University, Durham, NC Residency 1977 Internal Medicine
-UCSF, San Francisco, CA Fellowship 1980 Pulmonary Medicine

POSITIONS

1980 - 1984: Instructor in Medicine, University of California, San Francisco, CA
1984 - 1987: Assistant Professor of Medicine, University of California, San Francisco, CA
1985 - 1987: Associate Staff, Cardiovascular Research Instructor, University of California, San Francisco, CA
1987 - 1990: Assistant Professor of Medicine, Washington University School of Medicine, St. Louis, MO
1990 - 1995: Associate Professor of Medicine, Washington University School of Medicine, St. Louis, MO
1992 - present: Director, Pulmonary & Critical Care Medicine, Washington University School of Medicine
1994 - 1999: Associate Professor of Cell Biology & Physiology, Washington University School of Medicine
1995 - present: Professor of Medicine, Washington University School of Medicine, St. Louis, MO
1999 - present: Professor of Cell Biology & Physiology, Washington University School of Med., St. Louis, MO

HONORS (selected)

Alpha Omega Alpha, 1973
NIH Clinical Investigator Award, 1980
American Physiological Society, 1983
Francis S. North Senior Fellowship, 1985 and 1986
Academic Senate Committee on Research Award, UCSF, 1986
American Society for Biochemistry and Molecular Biology, 1988
Central Society for Clinical Research, 1988
American Lung Association Career Investigator Award, 1988
American Academy of Allergy and Immunology, 1990
Editorial Board, Am. J. Physiol: Lung Cell. Mol. Physiol. 1992-present
Associate Editor, Am. J. Respir. Cell Mol. Biol. 1992-1998
Ehrlanger-Graham Society, 1993; American Society for Clinical Investigation, 1993
NIH Lung Biology and Pathology Study Section, 1994-1998
Seldin Professorship of Medicine in Pulmonary Diseases, 1994-present
American Association of Immunologists, 1995
Editor-in-Chief, Am. J. Respir. Cell Mol. Biol. 1998-present
Fellow, American College of Chest Physicians, 1999
American Society for Microbiology, 1999
Association of American Physicians, 2000
Recognition for Scientific Accomplishments Award, American Thoracic Society, 2001.

PUBLICATIONS

RESEARCH SUPPORT

P50 HL56419
09/30/01 - 08/31/06
20% effort
NIH, NHLBI
“Mechanisms of Airway Inflammation and Remodeling (SCOR Grant)”
Project 2 “Immune cell traffic: Viral-allergic interactions”
This project is aimed at defining the cellular and molecular mechanisms underlying synergy between allergen and respiratory virus in the setting of airway inflammation, hyperreactivity, and remodeling.
Role: Principal Investigator/Project Leader

P50 HL56419 09/30/01 - 08/31/06
20% effort
NIH, NHLBI
“Mechanisms of Airway Inflammation (SCOR Grant)”
Project 3 “Epithelial-Immune Cell Interaction: Stat1-Dependent Gene Regulation”
This project is aimed at understanding how airway epithelial cells modulate the immune and inflammatory response using the Stat1-dependent gene network.
Role: Principal Investigator/Project Leader

P50 HL56419 09/30/01 - 08/31/06
5% effort
NIH, NHLBI
“Mechanisms of Airway Inflammation (SCOR Grant)”
Core A “Administrative”
This core provides programmatic and budgetary support as well as centralized computer support services to SCOR personnel.
Role: Principal Investigator/Project Leader

T32 HL07317-26 07/01/98 - 06/30/08
5% effort
NIH, NHLBI
“Principles in Pulmonary Research Training Grant”
This grant supports the research program for pre- and post-doctoral trainees based in the Division of Pulmonary and Critical Care Medicine at Washington University School of Medicine.
Role: Principal Investigator

RO1 HL073159-01 07/01/03 - 06/30/07
20% effort
NIH, NHLBI
“Basis of Long-Term Virus-Induced Goblet Cell Hyperplasia”
The project aims to define how specific candidate genes control long-term virus induced goblet cell hyperplasia and how immune cells mediate this response, focusing at present on the role of Clca1/3 in humans and in mice.
Role: Principal Investigator

P01 HL29594-01 09/01/03 - 08/31/08
20% effort
NIH, NHLBI
“Mechanisms in the Remodeling of Lung Structure (PPG)”
Project 5 – “Basis of Airway Epithelial Cell Survival”
The major goal of this PPG is to understand the molecular basis for remodeling of lung structure during inflammation and disease. Project 5 focuses on EGF receptor-dependent control of apoptosis in ciliated epithelial cells.
Role: Project Leader

RO1 HL64093 09/30/99 - 08/31/04*
0% effort
NIH, NHLBI
“Virus-Inducible Remodeling of Airway Epithelium”
The proposal aims to understand how paramyxoviral respiratory infections modify airway epithelial cell survival and proliferation pathways.
Role: Principal Investigator
*No costs extension granted

RO1 HL61031 07/01/98 - 06/30/04*
0% effort
NIH, NHLBI
“Virus-Induced Gene Expression in Airway Epithelial Cells”
This project aims to define the post-transcriptional mechanisms for virus-inducible expression of the RANTES gene in isolate human airway epithelial cells and the role of RANTES in a mouse model of viral infection.
Role: Principal Investigator
*No costs extension granted

Division of Pulmonary and Critical Care Medicine
Department of Medicine
Washington University School of Medicine