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Mario Castro, MD, MPH Associate Professor of Medicine
CONTACT INFORMATION
Washington University School of Medicine EDUCATION/TRAINING
University of Missouri 1988 BA Biology POSITIONS 2003 - present Adjunct Associate Professor of Community Health, St. Louis University School of Public Health, St. Louis, MO. 2002 - present Associate Professor of Medicine, Washington University School of Medicine, St. Louis, MO. 1994 - 2002 Assistant Professor of Medicine, Washington University School of Medicine, St. Louis, MO. 1994 - present Director, Pulmonary Function Laboratory, The Asthma Center, Washington University School of Medicine, St. Louis, MO. 1994 - present Attending Physician, Medical Service, Barnes-Jewish Hospital, St. Louis, MO PUBLICATIONS Castro M, Morgenthaler TI, Hoffman OA, Standing JE, Rohrbach MS, Limper AH: Pneumocystis carinii induction of arachidonic acid and its metabolites produced by alveolar macrophages. Am J Respir Cell Mol Biol 1993; 9:73-81. Castro M, Ralston NVC, Morgenthaler TI, Rohrbach MS, Limper AH: Candida albicans stimulates arachidonic acid liberation from alveolar macrophages through a-mannan and b-glucan cell wall components. Infect Immun 1994; 62:3138-3145. Castro M, Shepherd CW, Gomez MR, Lie JT, Ryu JH. Pulmonary tuberous sclerosis. Chest. 1995. 107:189-195. Castro M, Bjoraker JA, Rohrbach MS, Limper AH. Candida albicans induces the release of inflammatory mediators from human peripheral blood monocytes. Inflammation. 1996. 20:107-122. Castro M, Veeder MH, Mailliard JA, Tazelaar HD, Jett JR. A prospective study of pulmonary function in patients receiving Mitomycin C. Chest. 1996. 109:939-44. Castro M, Krowka MJ, Schroeder DR, Beck KC, Plevak DJ, Rettke SR, Cortese DA, Wiesner RH. Frequency and clinical implications of elevated pulmonary artery pressures in liver transplant patients. Mayo Clinic Proc. 1996. 71:543-551. Holtzman MJ, Sampath D, Castro M, Look DC, Jayaraman S. "The one-two of T helper cells: does interferon-g knockout the Th2 hypothesis for asthma," Am J Respir Cell Mol Biol. 1996. 14:316-18. Castro M. Treatment and prophylaxis of Pneumocystis carinii Pneumonia. Sem Resp Infect. 1998. 13:296-303. Holtzman MJ, Look DC, Walter MJ, Sampath D, Castro M. Control of epithelial immune-response genes and implications for airway immunity and inflammation. Proc. Assoc. Am. Phys. 1998. 110:1-11. Taguchi, M, Sampath D, Koga T, Castro M, Look DC, Nakajima S, Holtzman MJ. Patterns for RANTES secretion and ICAM-1 expression mediate transepithelial T cell traffic based on analyses in vitro and in vivo. J Exp Med. 1998. 187:1927-1940. Castro M, Smith T, Strunk RC. "Pathophysiology of Asthma," in Pediatric Asthma, Eds: Murphy S, Kelly HW, McWilliams B, New York: Marcel Dekker, pg. 71-115; 1998. Castro M, Marvel J, Hamilos DL, Holtzman MJ. Inflammatory cell influx in asthma precedes changes in pulmonary function following inhaled corticosteroid (ICS) withdrawal. Asthma '99 Theory to treatment. 1999. A56. Jayaraman S, Castro M, O'Sullivan M, Bragdon MJ, Holtzman MJ. Resistance to Fas-mediated T-cell apoptosis in asthma. J Immunol. 1999, 162:1717-1722. Sampath D, Castro M, Look DC, Holtzman MJ. Constitutive activation of an epithelial signal transducer and activator of transcription (Stat) pathway in asthma. J Clin Invest. 1999, 103:1353-1361. Castro M (Assoc Ed). Asthma. In Yearbook of Pulmonary Disease 2000. Ed: Jett J. St. Louis, MO: Mosby, pg. 1-77; 2000. Castro M. Ch. 27 An Overview of the Respiratory System, Ch. 28 Mechanical Aspects of Breathing, Ch. 29 Pulmonary and Bronchial Circulations and the Distribution of Ventilation and Perfusion, Ch. 30 Transport of Oxygen and Carbon Dioxide Between Lungs and Cells of the Body, Ch. 31 Control of Breathing. In Principles of Physiology, 3rd ed. Eds: Berne RM, Levy MN. St. Louis, MO: Mosby, 2000 Castro M, Robertson L, Jenkersen M, Li Q, Bloch S, Storch G, Chatila T, Bacharier L, Strunk R. Respiratory synctial virus (RSV) induces RANTES production in infants - Initial results from the RBEL study - RSV Bronchiolitis in Early Life. Am J Rev Crit Care Med 2000; 161:A898. Castro M, Chaplin DD, Walters MJ, Holtzman MJ. Could asthma worsen by stimulating the T helper type 1 (Th1) immune response? Am J Respir Cell Mol Biol 2000; 22:143-146. Chauhan B, Santiago L, Hutcheson PS, Schwartz HJ, Spitznagel E, Castro M, Slavin RG, Bellone CJ. Evidence for the involvement of two different MHC class II regions in susceptibility or protection in allergic bronchopulmonary aspergillosis. J All Clin Immunol. 2000,106:723-729. Pittman A, Castro M. Asthma. The Washington Manual of Medical Therapeutics, 30th ed. Philadelphia: Lippincott, Williams & Wilkins, 2001; pg. 241-255, 2001. Walter MJ, Kajiwara N, Karanja P, Castro M, Holtzman MJ. IL-12 p40 production by barrier epithelial cells during airway inflammation. J Exp Med. 2001, 193:339-351. Leawoods J, Gierada D, Yablonskiy D, Conrad M, Castro M, Saam B. Characterization of multiple ventilation defects in asthma with 3He. Proceedings of: International Society Magnetic Resonance Medicine, 2001. Horiuchi T, Castro M. The pathobiologic implications for treatment: "Old and new strategies in the treatment of chronic asthma" Clinics in Chest Medicine. Philadelphia: W.B. Saunders, pg. 381-395; 2000. Horiuchi T, Castro M, Morton JD, Bloch SR, Holtzman MJ. Airway remodeling following inhaled corticosteroid withdrawal in asthma. Am J Rev Crit Care Med . 2001. 163:A470. Castro M, SR Bloch, MV Jenkerson, DL Hamilos, MJ Holtzman, TK Horiuchi. RANTES induction in asthma, following inhaled corticosteroid (ICS) withdrawal, is not dependent upon nuclear factor kB (NF-kB). Am J Rev Crit Care Med. 2001. 163:A438. Horiuchi T, Castro M. Inhaled steroids Ð The mainstay of asthma therapy. J Resp Dis. 2001, 22:358-368. Castro M, Halstead J, Schechtman KB, Bloomberg G. Determinants of asthma morbidity and mortality in a large metropolitan city. J. Asthma 2001; 38:1-12 Castro M for The American Lung Association Asthma Clinical Research Centers. Safety of inactivated influenza vaccine in children and adults with asthma. N Engl J Med. 2001; 345:1529-1536. Bacharier LB, Jenkerson M, Robertson L, Tegtmeier L, White D, Castro M. Predictors of bronchodilator (BD) response after severe respiratory syncytial virus (RSV) bronchiolitis Results from the RSV Bronchiolitis in Early life (RBEL) study. Am J Rev Crit Care Med 2002; 165:A183. Hanania NA, Sockrider M, Weiss R, Castro M, Tonascia J, Atmar R. Immune response to influenza vaccine in patients with asthma lack of effect of corticosteroid therapy. Am J Rev Crit Care Med 2002; 165:A561. Bradley J, Tegtmeier L, Robertson L, Schechtman K, Bacharier L, Strunk R, Castro M. Severity of respiratory synctial virus (RSV) Bronchiolitis is affected by cigarette smoke exposure and atopy. Am J Rev Crit Care Med 2002; 165:A127. Ide K, Morton JD, You Y, Castro M, Brody SL, Holtzman MJ. Selective expression and function of epidermal growth factor receptor (EGF-R) on ciliated airway epithelial cells. Am J Rev Crit Care Med 2002; 165:A651. Walter MJ, Kajiwara N, Fan G, Karanja P, Friedman E, Castro M, Holtzman MJ. Production of IL-12 p40 by airway epithelial cells during viral infection and asthma supports a new paradigm for mucosal inflammation. Am J Rev Crit Care Med 2002; 165:A699. Hanania NA, Castro M. Chapter 252: Asthma "Add-on therapy for asthma: Leukotriene modifiers vs. long-acting beta-agonists". Harrison's Online. 2002. New York: McGraw-Hill www.harrisonsonline.com Castro M. The inactivated influenza vaccine is safe in patients with stable asthma. American College of Physicians Journal Club. 2002. Jul-Aug;137:18.. Castro M. Near fatal asthma - What have we learned? Chest 2002. 121:1394-1395. Cohen L, Castro M. The role of respiratory infection in the pathogenesis and progression of asthma. Sem Resp Infect. 2003. 18:3-8 Castro M, Zimmermann N, Crocker S, Bradley J, Levin C, Schechtman KB. Asthma intervention program prevents readmissions in high healthcare utilizers. Am J Resp Crit Care Med. 2003. In Press. Castro M, Bloch SR, Jenkerson MV, DeMartino S, Hamilos DL, Schechtman KB, Holtzman MJ. Asthma exacerbations after glucocorticoid withdrawal reflect T cell but not eosinophil recruitment to the airway. Submitted, 2003. Strunk RC, Castro M, Schootman M, Glynn E, Olish M, Moonie S, Crocker S, The Community Asthma Program: A program to change the approach to care of children with asthma in the primary care setting. Submitted, 2003. Hanania NA, Sockrider M, Castro M, Holbrook JT, Tonascia J, Wise R, Atmar RL for The American Lung Association Asthma Clinical Research Centers. Immune response to influenza vaccination in children and adults with asthma. Effect of corticosteroidtherapy. Submitted, 2003. Bacharier L, Schechtman K, Jenkerson M, Robertson L, Tegtmeier L, White D, Strunk RC, Castro M. Pulmonary function and bronchodilator response in infants following hospitalization for respiratory syncytial virus bronchiolitis. Submitted, 2003. Jani A, Shifren A, Grayson M, Castro M. Ch. 10 Allergy and Immunology. The Washington Manual of Medical Therapeutics, 31st ed. Philadelphia: Lippincott, Williams & Wilkins, 2004, In press.
RESEARCH SUPPORT
ONGOING
2R01 HL61895-04 09/01/98 - 08/31/07
P50 HL 56419-06 09/30/01 - 08/31/06
R01 HL69149-01 09/30/01 - 06/30/06
U59/CCU 720714-01 09/30/01 - 09/29/03
Division of Pulmonary and Critical Care Medicine
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