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Research Clinical Research Mario Castro, M.D., MPHMy translational research projects are in the area of pathogenesis of asthma and health-care delivery issues in asthma. We have a prospective cohort study, called the Respiratory synctial virus (RSV) Bronchiolitis in Early Life (RBEL) study, sponsored by the NIH, which is seeking to understand the genetic, biologic, and immunologic determinants of asthma in infants hospitalized with RSV bronchiolitis. We also have a study in Airway Remodeling in Severe Asthma grant, sponsored by the NIH, which is seeking to understand the molecular basis for airway remodeling in children and adults with severe asthma and how it differs from mild-to-moderate asthma. Our laboratory runs the Clinical Core of a NIH sponsored SCOR grant on the Molecular and Cellular Mechanisms of Asthma at Washington University School of Medicine. We also have an American Lung Association Asthma Clinical Research Center and NIH sponsored Asthma Clinical Research Network center which aim to conduct large multicenter studies to develop new approaches to asthma management and treatment. Lastly, we have a grant from the CDC and The St. Louis Asthma Regional Consortium focusing on improving how asthma care is delivered in the primary care setting.Murali Chakinala, M.D.My clinical research interests involve outcomes after lung transplantation, including the management of acute rejection and other medical complications of the post-transplant patient. I am also interested in the diagnosis and managment of patients with pulmonary arterial hypertension, particularly therapeutic trials.Marin H. Kollef, M.D.My research deals with the evaluation of patient outcomes in the ICU setting in order to develop a systematic approach to the improvement of their medical care. Stephen S. Lefrak, M.D.My major research interest is in pulmonary physiology, especially in chronic obstructive lung disease. As the Medical Director of the lung volume reduction program, the majority of our interests are in clarifying the selection criteria for this surgery and broadening our understanding of the physiologic changes which result. As Director of the medical school's Humanities Program in Medicine, we are involved in sponsoring research relating to medical ethics and the doctor patient relationship. John P. Lynch, M.D.My research interests are focused on the clinical aspects of the management of lung transplant patients. Specifically, we are studying health related quality of life in lung transplant recipients. We are also involved with multi-center trials that are aimed at improving immunosuppression protocols as well as testing novel interventions that are designed to reduce the incidence of reperfusion injury in the lung allograft.Daniel B. Rosenbluth, M.D.I am interested in clinical outcomes in the care of adult patients with cystic fibrosis. This includes participation in clinical trials evaluating novel therapies of CF-related lung disease. Elbert P. Trulock III, M.D.My clinical interests and clinical research are in the area of end-stage lung disease and lung transplantation. Peter G. Tuteur, M.D.My research is based on development of clinical curriculum, health policy and healthcare delivery. My major clinical interest is occupation-associated lung disease. Roger D. Yusen, M.D., M.P.H.My research is focused on technology assessment in pulmonary medicine. Our research team has been studying the outcomes of patients with end-stage lung disease, especially patients with emphysema. We have been assessing interventions such as lung volume reduction surgery and lung transplantation. We are also studying issues related to the selection of patients for lung volume reduction surgery and/or lung transplant wait listing. My other research efforts have focused on venous thromboembolic disease treatments. Our research team has evaluated the efficacy and costs of low-molecular-weight heparin therapy, as well as the selection criteria for outpatient deep venous thrombosis low-molecular-weight heparin therapy. We are currently assessing the effectiveness of contrast enhanced helical CT as an initial diagnostic test for pulmonary embolism. We will be studying the efficacy of pentasaccharide for the treatment of deep venous thrombosis and pulmonary embolism.
Division of Pulmonary and Critical Care Medicine
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