Biographical Sketch

Research

Lung transplantation; advanced lung disease.

Publications

1. Sanchez JL, Kruger RM, Paranjothi S, Trulock EP, Lynch JP, Hicks C, Shannon WD, Storch GA. Relationship of cytomegalovirus viral load in blood to pneumonitis in lung transplant recipients. Transplantation 2001; 72:733-735.

2. Paranjothi S, Yusen RD, Kraus MD, Lynch JP, Patterson GA, Trulock EP. Lymphoproliferative disease after lung transplantation: comparison of presentation and outcome of early and late cases. J Heart Lung Transplant 2001; 20:1054-1063.

3. Mackinnon SE, Doolabh VB, Novak CB, Trulock EP. Clinical outcome following nerve allograft transplantation. Plastic & Reconstructive Surgery 2001; 107:1419-1429.

4. Jaramillo A, Naziruddin B, Zhang L, Reznik SI, Smith MA, Aloush AA, Trulock EP, Patterson GA, Mohanakumar T. Activation of human airway epithelial cells by non-HLA antibodies developed after lung transplantation: a potential etiological factor for bronchiolitis obliterans syndrome. Transplantation 2001; 71:966-976.

5. Levy NT, Liapis H, Eisenberg PR, Botney MD, Trulock EP. Pathologic regression of primary pulmonary hypertension in left native lung following right single-lung transplantation. J Heart Lung Transplant 2001; 20:381-384.

6. Starlin R, Reed N, Leeman B, Black J, Trulock E, Mundy LM. Acute flaccid paralysis syndrome associated with Echovirus 19, managed with pleconaril and intravenous immunoglobulin. Clin Infect Dis 2001; 33:730-732.

7. McKane BW, Trulock EP, Patterson GA, Mohanakumar T. Lung transplantation and bronchiolitis obliterans: an evolution in understanding. Immunologic Research 2001; 24:177-190.

8. Bui JD, Despotis GD, Trulock EP, Patterson GA, Goodnough LT. Fatal thrombosis after administration of activated prothrombin complex concentrates in a patient supported by extracorporeal membrane oxygenation who had received activated recombinant factor VII. J Thorac Cardiovasc Surg 2002; 124:852-854.

9. Hardinger KL, Cornelius LA, Trulock EP III, Brennan, DC. Sirolimus-induced leukocytoclastic vasculitis. Transplantation 2002; 74:739-743.

10. Boucek MM, Edwards LB, Keck BM, Trulock EP, Taylor DO, Mohacsi PJ, Hertz MI. The Registry of the International Society for Heart and Lung Transplantation: Fifth Official Pediatric Report – 2001 to 2002. J Heart Lung Transplant 2002; 21:827-840.

11. Hertz MI, Taylor DO, Trulock EP, Boucek MM, Mohacsi PJ, Edwards LB, Keck BM. The Registry of the International Society for Heart and Lung Transplantation: Nineteenth Official Report – 2002. J Heart Lung Transplant 2002; 21: 950-970.

12. Hertz MI, Mohacsi PJ, Boucek MM, Taylor DO, Trulock EP, Deng MC, Rowe AW. The Registry of the International Society for Heart and Lung Transplantation: past, present and future. J Heart Lung Transplant 2002; 21: 945-949.

13. Ciccone AM, Stewart KC, Meyers BF, Guthrie TJ, Battafarano RJ, Trulock EP, Cooper JD, Paterson GA. Does donor cause of death affect the outcome of lung transplantation? J Thorac Cardiovasc Surg 2002: 123:429-434.

14. Mendeloff EN, Meyers BF, Sundt TM, Guthrie TJ, Sweet SC, Shapiro S, Balzer DT, Trulock EP, Lynch JP, Pasque MK, Cooper JD, Huddleston CB, Patterson GA. Lung transplantation for pulmonary vascular disease. Ann Thorac Surg 2002; 73:209-217.

15. Lu KC, Jaramillo A, Lecha RL, Schuessler RB, Aloush A, Trulock EP, Mendeloff EN, Huddleston CB, Patterson GA, Mohanakumar T. Interleukin-6 and interferon-? gene polymorphisms in the development of bronchiolitis obliterans syndrome after lung transplantation. Transplantation 2002; 74:1297-1302.

16. Cassivi SD, Meyers BF, Battafarano RJ, Guthrie TJ, Trulock EP, Lynch JP, Cooper JD, Patterson GA. Thirteen-year experience in lung transplantation for emphysema. Ann Thorac Surg 2002: 74:1663-1669.

17. Lee R, Meyers BF, Sundt TM, Trulock EP, Patterson GA. Concomitant coronary artery revascularization to allow successful lung transplantation in selected patients with coronary artery disease. J Thorac Cardiovasc Surg 2002; 124:12501251.

18. Hertz MI, Mohacsi PJ, Taylor DO, Trulock EP, Boucek MM, Deng MC, Keck BM Edwards LB, Rowe AW. The Registry of the International Society for Heart and Lung Transplantation: introduction to the twentieth annual reports – 2003. J Heart Lung Transplant 2003; 22: 610-615.

19. Taylor DO, Edwards LB, Mohacsi PJ, Boucek MM, Trulock EP, Keck BM, Hertz MI. The Registry of the International Society for Heart and Lung Transplantation: Twentieth Official Heart Transplant Report – 2003. J Heart Lung Transplant 2003; 22:616-624.

20. Trulock EP, Edwards LB, Taylor DO, Boucek MM, Mohacsi PJ, Keck BM, Hertz MI. The Registry of the International Society for Heart and Lung Transplantation: Twentieth Official Adult Lung and Heart-Lung Report – 2003. J Heart Lung Transplant 2003; 22:625-635.

21. Kruger RM, Paranjothi S, Storch GA, Lynch JP, Trulock EP. Impact of prophylaxis with CytoGam alone on the incidence of CMV viremia in CMV-seropositive lung transplant recipients. J Heart Lung Transplant 2003; 22:754-763.

22. Hachem RR, Chakinala MM, Yusen RD, Lynch JP, Aloush AA, Patterson GA, Trulock EP. The predictive value of bronchiolitis obliterans syndrome stage 0-p. Am J Respir Crit Care Med 2004; 169:468-472.

23. Hachem RR, Chakinala MM, Yusen RD, Lynch JP, Aloush AA, Patterson GA, Trulock EP. Abdominal-pelvic lymphoproliferative disease after lung transplantation: presentation and outcome. Transplantation 2004: 77:431-437.

24. Shi R, Jang J, Jaramillo A, Steward NS, Aloush A, Trulock EP, Patterson GA, Suthanthiran M, Mohanakumar T. Correlation between interleukin-15 and granzyme B expression and acute lung allograft rejection. Transplant Immunol 2004; 12:103-108.

25. Khalifah AP, Hachem RR, Chakinala MM, Schechtman KB, Patterson GA, Schuster DP, Mohanakumar T, Trulock EP, Walter MJ. Respiratory viral infections are a distinct risk for bronchiolitis obliterans syndrome and death. Am J Respir Crit Care Med 2004; 170:181-187.

26. Pechet TT, Meyers BF, Guthrie TJ, Battafarano RJ, Trulock EP, Cooper JD, Patterson GA. Lung transplantation for lymphangioleiomyomatosis. J Heart Lung Transplant 2004; 23:301-308.

27. Young PP, Uzieblo A, Trulock E, Lublin DM, Goodnough LT. Autoantibody formation after alloimmunization: are blood transfusions a risk factor for autoimmune hemolytic anemia. Transfusion 2004; 44:67-72.

28. Trulock EP, Edwards LB, Taylor DO, Boucek MM, Keck BM, Hertz MI. The Registry of the International Society for Heart and Lung Transplantation: twenty-first official adult lung and heart-lung transplant report – 2004. J Heart Lung Transplant 2004; 23:804-815.

29. Taylor DO, Edwards LB, Boucek MM, Trulock EP, Keck BM, Hertz MI. The Registry of the International Society for Heart and Lung Transplantation: twenty-first official adult heart transplant report – 2004. J Heart Lung Transplant 2004; 23:796-803.

30. Boucek MM, Edwards LB, Keck BM, Trulock EP, Taylor DO, Hertz MI. Registry of the International Society for Heart and Lung Transplantation: seventh official pediatric report – 2004. J heart Lung Transplant 2004; 23:933-947.

31. Klepetko W, Mayer E, Sandoval J, Trulock EP, Vachiery JL, Dartevelle P, Pepke-Zaba J, Jamieson SW, Lang I, Corris P. Interventional and surgical modalities of treatment for pulmonary arterial hypertension. J Am Coll Cardiol 2004; 43(12 suppl S):73S-80S.

32. Parekh K, Trulock E, Patterson GA. Use of cyclosporine in lung transplantation. Transplant Proceed 2004; 36 (2 suppl):318S-322S.

33. Chakinala MM, Ritter J, Gage BF, Lynch JP, Aloush A, Patterson GA, Trulock EP. Yield of surveillance bronchoscopy for acute rejection and lymphocytic bronchitis/bronchiolitis after lung transplantation. J Heart Lung Transplant 2004; 23:1396-1404.

34. Jaramillo A, Fernandez FG, Kuo EY, Trulock EP, Patterson GA, Mohanakumar T. Immune mechanisms in the pathogenesis of bronchiolitis obliterans syndrome after lung transplantation. Ped Transplant 2005; 9:84-93.

35. Meyers BF, de la Morena M, Sweet SC, Trulock EP, Guthrie TJ, Mendeloff EN, Huddleston C, Cooper JD, Patterson GA. Primary graft dysfunction and other selected complications of lung transplantation: a single-center experience of 983 patients. J Thorac Cardiovasc Surg 2005; 129:1421-1429.

36. Chakinala MM, Ritter J, Gage BF, Aloush AA, Hachem, RH, Lynch JP, Patterson GA, Trulock EP. Reliability for grading acute rejection and airway inflammation after lung transplantation. J Heart Lung Transplant 2005; 24:652-657.

37. Hachem RR, Chakinala MM, Yusen RD, Lynch JP, Aloush AA, Patterson GA, Trulock EP. A comparison of basiliximab and anti-thymocyte globulin as induction agents after lung transplantation. J Heart Lung Transplant 2005; 24:1320-1326.

38. Hachem RR, Khalifah AP, Chakinala MM, Yusen RD, Aloush AA, Mohanakumar T, Patterson GA, Trulock EP, Walter MJ. The significance of a single episode of minimal acute rejection after lung transplantation. Transplantation 2005; 80:1406-1413.

39. Trulock EP, Edwards LB, Taylor DO, Boucek MM, Keck BM, Hertz MI. Registry of the International Society for Heart and Lung Transplantation: twenty-second official adult lung and heart-lung transplant report – 2005. J Heart Lung Transplant 2005; 24:956-967.

40. Parekh K, Meyers BF, Patterson GA, Guthrie TJ, Trulock EP, Damiano RJ Jr, Moazami N. Outcome of lung transplantation for patients requiring concomitant cardiac surgery. J Thorac Cardiovasc Surg 2005; 130:859-863.

41. Sumino KC, Agapov E, Pierce RA, Trulock EP, Pfiefer JD, Ritter JH, Gaudreault-Keener M, Storch GA, Holtzman MJ. Detection of severe human metapneumovirus infection by real-time polymerase chain reaction and histopathological assessment. J Infect Dis 2005; 1052-1060.

42. Khalifah AP, Hachem RR, Chakinala MM, Yusen RD, Aloush AA, Patterson GA, Mohanakumar T, Trulock EP, Walter MJ. Minimal acute rejection after lung transplantation: a risk factor for bronchiolitis obliterans syndrome. Am J Transplant 2005; 5:2022-2030.

43. Hachem RR, Yusen RD, Chakinala MM, Aloush AA, Patterson GA, Trulock EP. Thrombotic microangiopathy after lung transplantation. Transplantation 2006; 81:57-63.

44. Mikols CL, Yan L, Norris JY, Russell TD, Khalifah AP, Hachem RR, Chakinala MM, Yusen RD, Castro M, Kuo E, Patterson GA, Mohanakumar T, Trulock EP, Walter MJ. IL-12 p80 is an innate epithelial cell effector that mediates chronic allograft dysfunction. Am J Respir Crit Care Med 2006; 174:461-470.

45. Boucek MM, Waltz DA, Edwards LB, Taylor DO, Keck BM, Trulock EP, Hertz MI. Registry of the International Society for Heart and Lung Transplantation: ninth official pediatric heart transplantation report—2006. J Heart Lung Transplant 2006; 25:893-903.

46. Waltz DA, Boucek MM, Edwards LB, Keck BM, Trulock EP, Taylor DO, Hertz MI. Registry of the International Society for Heart and Lung Transplantation: ninth official pediatric lung and heart-lung transplantation report – 2006. J Heart Lung Transplant 2006; 25:904-911.

47. Trulock EP, Edwards LB, Taylor DO, Boucek MM, Keck BM, Hertz MI. Registry of the International Society for Heart and Lung Transplantation: twenty-third official adult lung and heart-lung transplantation report – 2006. J Heart Lung Transplant 2006; 25:880-892.

48. Taylor DO, Edwards LB, Boucek MM, Trulock EP, Waltz DA, Keck BM, Hertz MI. Registry of the International Society for Heart and Lung Transplantation: twenty-third official adult heart transplantation report – 2006. J Heart Lung Transplant 2006; 25:869-879.

49. Hertz MI, Boucek MM, Edwards LB, Keck BM, Rowe AW, Taylor DO, Trulock EP, Waltz DA. The ISHLT transplant registry: moving forward. J Heart Lung Transplant 2006; 25:1179-1185.

50. Fields RC, Bharat A, Steward N, Aloush A, Meyers BF, Trulock EP, Chapman WC, Patterson GA, Mohanakumar T. Elevated soluble CD30 correlates with development of bronchiolitis obliterans syndrome following lung transplantation. Transplantation 2006; 82:1596-1601.

51. Bharat A, Fields RC, Trulock EP, Patterson GA, Mohanakumar T. Induction of IL-10 suppressors in lung transplant patients by CD4+25+ regulatory T cells through CTLA-4 signaling. J Immunol 2006; 177:5631-5638.

52. Chen F, Hasegawa S, Bando T, Kitaichi M, Hiratsuka T, Kawashima M, Hanaoka N, Yosshimura T, Tanaka F, Trulock EP, Wada, H. Recurrence of bilateral diffuse bronchiectasis after bilateral lung transplantation. Respirology 2006; 11:666-668.

53. Bharat A, Fields RC, Steward N, Trulock EP, Patterson GA, Mohanakumar T. CD4+25+ regulatory T cells limit Th1-autoimmunity by inducing IL-10 producing T cells following human lung transplantation. Am J Transplant 2006; 6:1799-1808.

54. Choong CK, Meyers BF, Guthrie TJ, Trulock EP, Patterson GA, Moazami N. Does the presence of preoperative mild or moderate coronary artery disease affect the outcomes of lung transplantation? Ann Thorac Surg 2006; 82:1038-1042.

55. Daud SA, Yusen RD, Myers BF, Chakinala MM, Walter MJ, Aloush AA, Patterson GA, Trulock EP, Hachem RR. Impact of immediate primary lung allograft dysfunction on bronchiolitis obliterans syndrome. Am J Respir Crit Care Med 2007; 175:507-513.

56. Bharat A, Narayanan K, Street T, Fields RC, Steward N, Aloush A, Meyers B, Schuessler R, Trulock EP, Patterson GA, Mohanakumar T. Early posttransplant inflammation promotes the development of alloimmunity and chronic human lung allograft rejection. Transplantation 2007; 83:150-158.

57. Trulock EP, Christie JD, Edwards LB, Boucek, MM, Aurora P, Taylor DO, et al. Registry of the International Society for Heart and Lung Transplantation: Twenty-fourth official adult lung and heart-lung report – 2007. J Heart Lung Transplant 2007; 26:782-795.

58. Hachem RR, Yusen Rd, Chakinala MM, Meyers BF, Lynch JP, Aloush AA, Patterson GA, Trulock EP. A randomized controlled trial of tacrolimus versus cyclosporine after lung transplantation. J Heart Lung Transplant 2007; 26:1012-1018.

Book Chapters/Reviews

1. Trulock EP. Lung transplantation for primary pulmonary hypertension. In: Rich S, McLaughlin V (Ed). Pulmonary Hypertension. Clin Chest Med 2001: 22(3):583-593.

2. Trulock EP. Lung transplantation and COPD. In: Similowski T, Whitelaw WA, Derenne J-P (Ed). Clinical Management of Chronic Obstructive Pulmonary Disease. New York: Marcel Dekker, Inc.; 2002: 921-942. (Lenfant C, Ed. Lung Biology in Health and Disease).

3. Chakinala MM, Trulock EP. Acute allograft rejection after lung transplantation: diagnosis and therapy. In: Patterson GA (Ed). Lung transplantation. Chest Surg Clin NA 2003; 13:525-542.

4. Hachem RR, Trulock EP. Bronchiolitis obliterans syndrome: pathogenesis andmanagement. Sem Thorac Cardiovasc Surg 2004; 16:350-355.

5. Trulock EP, Patterson GA, Cooper JD. Chapter 248: Lung transplantation. In: Braunwald E, Kasper DL, Hauser SL, Fauci AS, Jameson JL, Longo DL (Ed.). Harrison’s Principles of Internal Medicine, 16th Edition. New York: McGraw-Hill; 2005: 1576-1579.

6. Chakinala MM, Trulock EP. Pneumonia in the solid organ transplant patient. Clin Chest Med 2005; 26:113-121.

7. Trulock EP. Chapter 29: Bronchiolitis obliterans syndrome. In: Franco KL, Putnam JB Jr. Advanced Therapy in Thoracic Surgery, Second Edition. Hamilton, Ontario: B. C. Decker Inc.; 2005: 367-377.

8. Trulock EP. XVII Lung Transplantation. In: Dale DC, Federman DD (Ed.). ACP Medicine. New York: WebMD Professional Publishing; 2007: Chapter 14, Respiratory Medicine.