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Adrian Shifren, M.D.
Adrian Shifren, M.D.

Adrian Shifren, M.D.

Assistant Professor of Medicine
Pulmonary & Critical Care Medicine

Washington University School of Medicine
660 S. Euclid Avenue, Campus Box 8052
St. Louis, MO 63110
(314) 454-8764 (phone)
(314) 454-5571 (fax)

ashifren@dom.wustl.edu

Research Interests

Emphysema, Pulmonary Hypertension

Biographical Sketch

Research

I work on genetic determinants of emphysema. I focus on the role of extracellular matrix molecules in predisposing to, or protecting from, emphysema. I use knockout and transgenic mouse models to investigate the mechanisms responsible for changes in emphysema susceptibility following cigarette-smoke exposure. I am also translating these findings to human disease by screening populations of emphysema patients for extracellular matrix molecule gene mutations that associate with clinical markers of disease.

Publications

1. Shifren A, Durmowicz GA, Kovacs A, Knutsen RH, Faury G, Mecham RP. Elastin Insufficiency Predisposes to Pulmonary Hypertension. (In Review).

2. Shifren A, Hall-Moore CM, Mecham RP, Pierce RA. Elastin Deficiency in Mice Limits Compensatory Lung Growth Following Pneumonectomy (In Review).

3. Hu Q, Shifren A, Choi J, Davis EC, Szabo Z, Starcher BC, Shipley JM, Knutsen RH, Mecham RP, Urban Z. Emphysematous Lung Disease in a Transgenic Mouse Model of Autosomal Dominant Cutis Laxa (In Review).

4. Werneck CC, Vicente CP, Weinberg JS, Shifren A, Pierce RA, Broekelmann TJ, Tollefsen DM, and Mecham RP. Mice Lacking the Extracellular Matrix Protein MAGP1 Display Delayed Thrombotic Occlusion Following Vessel Injury. Blood 2008 Feb 15; [Epub ahead of print].

5. Shifren A, Woods JC, Rosenbluth DB, Officer S, Cooper JD, Pierce RA. Upregulation of Elastin Expression in Constrictive Bronchiolitis Obliterans. Int J COPD 2007; 2(4).

6. Shifren A, Durmowicz GA, Knutsen RH, Hirano E, Mecham RP. Elastin Protein Levels are a Vital Modifier Affecting Normal Lung Development and Susceptibility to Emphysema (Am J Physiol Lung Cell Mol Physiol 2007, 292:L778-789.

7. Shifren A, Mecham RP. The Stumbling Block in Lung Repair: Elastic Fiber Assembly. Proc Am Thorac Soci 2006 Jul;3(5):428-33.

Book Chapters/Reviews

1. Shifren A, Cohen L, Castro M. Asthma. In: Shifren A ed. The Washington Manual Pulmonary Medicine Subspecialty Consult, The Washington Manual Subspecialty Consult Series, Philadelphia: Lippincott, Williams & Wilkins, 2006.

2. K. Cajal Sumino, Shifren A. Community-Acquired Pneumonia. In: Shifren A ed. The Washington Manual Pulmonary Medicine Subspecialty Consult, The Washington Manual Subspecialty Consult Series, Philadelphia: Lippincott, Williams & Wilkins, 2006.

3. Shifren A, Park J, Yusen RD. Chronic Obstructive Pulmonary Disease. In: Shifren A ed. The Washington Manual Pulmonary Medicine Subspecialty Consult, The Washington Manual Subspecialty Consult Series, Philadelphia: Lippincott, Williams & Wilkins, 2006.

4. Shifren A, Morrow LE. Interstitial Lung Diseases. In: Shifren A ed. The Washington Manual Pulmonary Medicine Subspecialty Consult, The Washington Manual Subspecialty Consult Series, Philadelphia: Lippincott, Williams & Wilkins, 2006.

5. Sivaprasad L, Shifren A. Pleural Diseases. In: Shifren A ed. The Washington Manual Pulmonary Medicine Subspecialty Consult, The Washington Manual Subspecialty Consult Series, Philadelphia: Lippincott, Williams & Wilkins, 2006.

6. Shifren A. Pulmonary Function Testing. In: Shifren A ed. The Washington Manual Pulmonary Medicine Subspecialty Consult, The Washington Manual Subspecialty Consult Series, Philadelphia: Lippincott, Williams & Wilkins, 2006.

7. Waheed S, Shifren A. Basic Radiology. In: Shifren A ed. The Washington Manual Pulmonary Medicine Subspecialty Consult, The Washington Manual Subspecialty Consult Series, Philadelphia: Lippincott, Williams & Wilkins, 2006.

8. Jani A, Shifren A, Grayson M, Castro M. Ch. 10 Allergy and Immunology. In: Green GB, Harris IS et al eds. The Washington Manual of Medical Therapeutics, 31st ed. Philadelphia: Lippincott, Williams & Wilkins, 2004.