Biographical Sketch

Research

I have developed the ICU into a research laboratory to investigate disease processes (e.g., ventilator-associated pneumonia) and patient outcomes.

Publications

1. Shorr AF, Chung K, Jackson WL, Waterman PE, Kollef MH. Fluconazole prophylaxis in critically ill surgical patients: insights from a meta-analysis. Crit Care Med 2005; 33:1928-1935.

2. Kollef MH, Shorr AF, Gupta V, Tabak Y, Johannes RS, Liu L. Epidemiology and outcomes of health care-associated pneumonia: results from a large US database of culture-positive pneumonia. Chest 2005; 128:3854-3862.

3. Shorr AF, Kunkel MJ, Kollef MH. Linezolid versus vancomycin for Staphylococcus aureus bacteremia: pooled analysis of randomized studies. J Antimicrob Chemother 2005; 56:923-929.

4. Kollef M, Pittet D, Sanchez Garcia M, Chastre J, Fagon JY, Bonten M, Hyzy R, Fleming TR, Fuchs H, Bellm L, Mercat A, Manez R, Martinez A, Eggimann P, Daguerre M. A randomized double-blind trial of iseganan in prevention of ventilator-associated pneumonia. Am J Respir Crit Care Med 2006; 173:91-97.

5. Shorr AF, Combes A, Kollef MH, Chastre J. Methicillin-resistant Staphylococcus aureus prolongs intensive care unit length of stay in ventilator-associated pneumonia-- despite initial therapy with vancomycin. Crit Care Med 2006; 34:700-706.

6. Rello J, Kollef MH, Draz E, Sandiumenge A, Castillo Y, Corbella X, Zachskorn R. Reduced burden of bacterial airway colonization with a novel silver-coated endotracheal tube in a randomized multicenter feasibility study. Crit Care Med 2006; 34:2766-2772.

7. Micek ST, Roubinian N, Heuring T, Bode M, Williams J, Harrison C, Prentice D, Ruoff B, Kollef MH. A before-after study of a standardized hospital order set for the management of septic shock. Crit Care Med 2006; 34:2707-2713.

8. Shorr AF, Tabak YP, Killian AD, Gupta V, Liu LZ, Kollef MH. Healthcare-associated bloodstream infection: A distinct entity? Insights from a large U.S. database. Crit Care Med 2006; 34:2588-2595.

9. Schramm GE, Johnson J, Doherty JA, Micek ST, Kollef MH. Methicillin-resistant Staphylococcus aureus sterile-site infection: the importance of appropriate initial antimicrobial treatment. Crit Care Med 2006; 34:2069-2074.

10. Shadel BN, Puzniak LA, Lawrence SJ, Kollef MH, Mundy LM. Surveillance for vancomycin-resistant Enterococci: type, rates, costs, and implications. Infect Control Hosp Epidemiol 2006; 27:1068-1075.

11. Metheny NA, Clouse RE, Chang YH, Stewart BJ, Oliver DA, Kollef MH. Tracheobronchial aspiration of gastric contents in critically ill tube-fed patients: frequency, outcomes, and risk factors. Crit Care Med 2006; 34:1007-1015.

12. Kollef MH, Leeper KV, Anzueto A, Morrow LE, Benz-Scott L, Niederman MS. Clinical characteristics and treatment patterns among patients with ventilator-associated pneumonia. Descriptive findings from the Assessment of Local Antimicrobial Resistance Measures (ALARM) study. Chest 2006; 129:1210-1218.

13. Shorr A, Tabak YP, Gupta V, Johannes RS, Liu LZ, Kollef MH. Cost burden of methicillin resistant Staphylococcus aureus in ventilator-associated pneumonia. J Crit Care 2006; 10:1-7.

14. Jeffres M, Isakow W, Doherty JA, McKinnon PS, Ritchie DJ, Micek ST, Kollef MH. Predictors of mortality for methicillin-resistant Staphylococcus aureus healthcare-associated pneumonia: lack of a treatment effect related to vancomycin pharmacokinetic indices. Chest 2006; 130:947-955.

15. Kollef MH, Shorr AF, Tabak YP, Gupta V, Liu LZ, Johannes RS. Healthcare-associated pneumonia. Implications to hospitals. Managing Infect Control 2006; 6:38-44.

16. Merz LR, Warren DK, Kollef MH, Fridkin SK, Fraser VJ. The impact of an antibiotic cycling program on empirical therapy for gram-negative infections. Chest 2006; 130:1672-1678.

17. McMullen KM, Zack J, Prentice D, Sona C, Coopersmith C, Kollef MH, Warren D. The use of hypochlorite solution to lower rates of Clostridium difficile-associated diarrhea. Infect Control Hosp Epidemiol 2007; 28:205-207.

18. Lawrence SJ, Puzniak LA, Shadel BN, Gillespie KN, Kollef MH, Mundy LM. Clostridium difficile in the intensive care unit: epidemiology, costs, and colonization pressure. Infect Control Hosp Epidemiol 2007; 28:123-130.

19. Deal EN, Micek ST, Ritchie DJ, Reichely RM, Kollef MH. Predictors of in-hospital mortality for bloodstream infection caused by Enterobacter species or Citrobacter freundii. Pharmacotherapy 2007; 27:191-199.

20. Schramm GE, Johnson J, Doherty JA, Micek ST, Kollef MH. Increasing incidence of sterile-site infections due to community-associated methicillin-resistant Staphylococcus aureus among hospitalized patients. 2007; 28:95-97.

21. Harris CB, Krauss MJ, Coopersmith C, Nast PA, Kollef MH, Dunagan WC, Fraser VJ. Patient safety event reporting in critical care: an observational study of three intensive care units. Crit Care Med 2007; 35:1068-1076.

22. Shorr AF, Kollef MH. Do clinical features allow for accurate prediction of fungal etiology in bloodstream infections? Potential implications of the increasing prevalence of non-albicans Candidemia. Crit Care Med 2007; 35:1077-1083.

23. Micek ST, Shah P, Hollands JM, Shah RA, Shannon WD, Kollef MH. Addition of vasopressin to norepinephrine as independent predictor of mortality in patients with refractory septic shock: an observational study. Surg Infect 2007; 8:189-200.

24. Shorr AF, Micek ST, Kollef MH. Economic implications of a sepsis protocol: can we improve outcomes and save lives? Crit Care Med 2007; 35:1257-1262.

25. Jeffres M, Isakow W, Doherty JA, McKinnon PS, Ritchie JD, Micek ST, Kollef MH. Renal toxicity associated with aggressive vancomycin dosing for treatment of Staphylococcus aureus healthcare-associated pneumonia. Clin Ther 2007; 29:1107-1115.

26. Kenneally C, Rosini JM, Skrupky LP, Doherty JA, Hollands JM, Martinez E, McKenzie W, Murphy T, Smith JR, Micek ST, Kollef MH. Predictors of thirty-day mortality for Clostridium difficile-associated disease in the ICU setting. Chest 2007; 132:418-424.

27. Micek ST, Kollef KE, Reichley R, Roubinian N, Kollef MH. Healthcare-associated pneumonia and community-acquired pneumonia: a single center experience. Antimicrob Agents Chemother 2007; 51:3568-3573.

28. Kaynar AM, Mathew JJ, Hudlin MM, Gingras DJ, Ritz RH, Jackson MR, Kacmarek RM, Kollef MH. Attitudes of respiratory therapists and nurses about measures to prevent ventilator-associated pneumonia: a multicenter, cross-sectional survey study. Respir Care 2007; 52:1687-1694.

29. Kollef KE, Reichley RM, Micek ST, Kollef MH. The modified APACHE II score outperforms CURB65 pneumonia severity score as a predictor of thirty-day mortality in MRSA pneumonia. Chest 2008; 133:363-369.

30. Hamburg B, Storch G, Kollef MH. The importance of early treatment with doxycycline in human ehrlichiosis. Medicine 2008; 87:53-60.

Book Chapters/Reviews

1. Isakow W, Kollef MH. Preventing ventilator-associated pneumonia: an evidence-based approach of modifiable risk factors. Semin Respir Crit Care Med 2006; 27:5-16.

2. Shorr AF, Jackson WL, Kollef MH. Fluconazole prophylaxis. Crit Care Med 2006; 34:584-586.

3. Kollef MH. Providing appropriate antimicrobial therapy in the intensive care unit: surveillance vs. de-escalation. Crit Care Med 2006; 34:903-904.

4. Kollef MH. The ICU as a research laboratory: developing strategies to prevent antimicrobial resistance. Surg Infect 2006; 7:85-99.

5. Kollef MH. Is antibiotic cycling the answer to preventing the emergence of bacterial resistance in the intensive care unit? Clin Infect Dis 2006; 43:S1-S7.

6. Kollef MH. Antibiotic cycling and alternative strategies for preventing the emergence of bacterial resistance. Infect Med 2006; 23:199-204.

7. Kollef MH. Microbiologic diagnosis of ventilator-associated pneumonia: using the data to optimize clinical outcomes. Am J Respir Crit Care Med 2006; 173:1182-1184.

8. Kollef MH. The role of antibiotics in the management of serious hospital-acquired infections. Medscape Website 2006.

9. Daud SA, Kollef MH. Hospital-acquired pneumonia. In: The Washington Manual, Pulmonary Medicine Subspecialty Consult. Shifren A, Lin TL, Goodenberger DM (eds). Lippincott Williams and Wilkins (2006) 84-89.

10. Kollef MH. Time to get serious about infection prevention in the ICU. Chest 2006; 130:1293-1296.

11. Kollef MH. Diagnosis of ventilator-associated pneumonia. N Engl J Med 2006; 355:2691-2693.

12. Micek ST, Kollef MH. A before-after study of a standardized hospital order set for the management of septic shock. Crit Care Med 2006; 34:2707-2713.

13. Kollef MH. Prevention of Nosocomial Respiratory Infections. In: Nosocomial Infections. Woodhead M, Ewig S, Mandell L, Torres A (Eds). Hodder Arnold (2006): 875-693.

14. Kollef MH. Moving towards real-time antimicrobial management of ventilator-associated pneumonia. Clin Infect Dis 2007; 44:388-390.

15. Isakow W, Kollef MH. Book Review- Principles and practice of mechanical ventilation, 2nd edition. N Engl J Med 2007; 356:2001.

16. Kollef MH, Shorr AF, Micek ST. Clinicians Primer: Nosocomial pneumonia - a clinician’s guide to diagnosis, treatment, resistance, and future directions. Feb 2007.

17. Rello J, Kollef MH. Silver-coated endotracheal tubes- Is the bactericidal effect time limited? Crit Care Med 2007; 35:987.

18. Driscoll J, Brody S, Kollef MH. Pseudomonas infection. Drugs 2007; 67:351-368.

19. Micek ST, Kollef MH. Using protocols to improve the outcomes of critically ill patients with infections: focus on ventilator-associated pneumonia and severe sepsis. In: Infectious Disease in Critical Care. Rello J, Kollef M, Diaz E, Rodriguez A (eds). Springer (2007) 78-89.

20. Isakow W, Morrow L, Kollef MH. Probiotics for preventing and treating nosocomial infections: review of current evidence and recommendations. Chest 2007; 132:286-294.

21. Kollef MH. Bugging the bugs: novel approaches in the strategic management of resistant Staphylococcus aureus infections. Clin Infect Dis 2007; 45:S163-S164.

22. Kollef MH. Limitations of vancomycin in the management of resistant Staphylococcal infections. Clin Infect Dis 2007; 45:S191-195.

23. Kollef MH. The impact of toxin inhibition on Gram-positive infection: focus on methicillin-resistant Staphylococcus aureus expressing the Panton-Valentine leukocidin gene. General Surgery News 2007.

24. Kollef MH. Management of shock: Introduction. In: The Washington Manual of Critical Care. Kollef MH, Bedient TJ, Isakow W, Witt CA (eds). Lippincott Williams and Wilkins (2007).

25. Kollef MH. Hypovolemic shock. In: The Washington Manual of Critical Care. Kollef MH, Bedient TJ, Isakow W, Witt CA (eds). Lippincott Williams and Wilkins (2007).

26. Kollef MH. Septic shock. In: The Washington Manual of Critical Care. Kollef MH, Bedient TJ, Isakow W, Witt CA (eds). Lippincott Williams and Wilkins (2007).

27. Kollef MH, Witt CA. Acute exacerbation of chronic obstructive lung disease. In: The Washington Manual of Critical Care. Kollef MH, Bedient TJ, Isakow W, Witt CA (eds). Lippincott Williams and Wilkins (2007).

28. Bedient T, Kollef MH. Adrenal insufficiency. In: The Washington Manual of Critical Care. Kollef MH, Bedient TJ, Isakow W, Witt CA (eds). Lippincott Williams and Wilkins (2007).

29. Kollef MH. Nosocomial pneumonia. In: The Washington Manual of Critical Care. Kollef MH, Bedient TJ, Isakow W, Witt CA (eds). Lippincott Williams and Wilkins (2007).

30. DeBlieux P, Kollef MH. A new paradigm in emergency medicine: healthcare-associated pneumonia. Clin Courier 2007; 25:1-12.