Biographical Sketch

Research

My research is patient-oriented and primarily involves patients with pulmonary vascular disorders.

I am (local) principal investigator for several multi-centered clinical investigations for the treatment of pulmonary arterial hypertension. I am also studying non-invasive techniques for the longitudinal assessment of patients with pulmonary arterial hypertension, including application of a bed-side Doppler machine for rapid flow (cardiac output) assessment.

I am interested in the application of multi-planar computed tomography (CT) for the initial diagnosis and follow-up of pulmonary arterio-venous malformations in patients with hereditary hemorrhagic telangiectasia.

Publications

1. Daud SA, Yusen RD, Meyers BF, Chakinala MM, Walter MJ, Aloush AA, Patterson GA, Trulock EP, Hachem RR. Impact of Immediate Primary Lung Allograft Dysfunction on Bronchiolitis Obliterans Syndrome. Am J Respir Crit Care Med. 2007; 175: 507-513.

2. Mikols, C.L., Yan, L., Norris, J.Y., Russell, T.D., Khalifah, A.P., Hachem, R.R., Chakinala, M.M., Yusen, R.D., Castro, M., Kuo, E., Patterson, G.A., Mohanakumar, T., Trulock, E.P., Walter, M.J. IL-12 p80 Is an Innate Epithelial Cell Effector That Mediates Chronic Allograft Dysfunction. Am J Respir Crit Care Med. 2006. 174:461-470.

3. Sumino KC and Chakinala MM. A 45-year-old female with a history of dyspnea. (case presentation of bosentan for the treatment of pulmonary hypertension associated with Pulmonary Langerhans’ Cell Histiocytosis). Breathe. 2006; 2(3): 11-14.

4. Hachem RR, Yusen RD, Chakinala MM, Aloush AA, Patterson GA, Trulock EP. Thrombotic microangiopathy after lung transplantation. Transplantation. 2006; 81: 57-63.

5. Hachem RR, Khalifah AP, Chakinala MM, Yusen RD, Aloush AA, Mohanakumar T, Patterson GA, Trulock EP, and Walter MJ. The Significance of a Single Episode of Minimal Acute Rejection after Lung Transplantation. Transplantation. 2005; 80: 1406-13.

6. Khalifah AP, Hachem RR, Chakinala MM, Yusen RD, Aloush A, Patterson GA, Mohanakumar T, Trulock EP, Walter MJ. Minimal Acute Rejection after Lung Transplantation: A Risk for Bronchiolitis Obliterans Syndrome. Am J Transplant. 2005; 5: 2022-30.

7. Hachem RR, Chakinala MM, Yusen RD, Lynch JP, Aloush AA, Patterson GA, Trulock EP. A Comparison of Basilixmab and Anti-Thymocyte Globulin as Induction Agents after Lung Transplantation. J Heart Lung Transplant. 2004; 24: 1320-26

8. Chakinala MM, Ritter J, Gage BF, Aloush AA, Hachem RH, Lynch JP, Patterson GA, and Trulock EP. Reliability for Grading Acute Rejection and Airway Inflammation after Lung Transplantation. Journal of Heart Lung Transplantation. 2005; 24: 652-57.

9. Khalifah AP, Hachem RR, Chakinala MM, Schectman KB, Patterson GA, Schuster DP, Trulock EP, Walter MJ. Community-Acquired Respiratory Viral Infections Increase the Risk of Developing Bronchiolitis Obliterans Syndrome in 259 Consecutive Lung Transplant Recipients. Am J Respir Crit Care Med. 2004;170: 181-87.

10. Hachem R, Chakinala MM, Yusen RD, Lynch JP, Aloush AA, Patterson GA, and Trulock EP. The Predictive Value of Bronchiolitis Obliterans Syndrome, Stage O-p. Am J Respir Crit Care Med. 2003; 169: 468-472.

11. Chakinala MM, Ritter J, Gage BF, Aloush AA, Patterson GA, Trulock EP. Yield of Surveillance Bronchoscopy for Acute Rejection and Lymphocytic Bronchitis/Bronchiolitis After Lung Transplantation. Journal of Heart Lung Transplantation. 2004; 23: 1396-1404.

12. Hachem R, Chakinala MM, Yusen RD, Lynch JP, Aloush AA, Patterson GA, and Trulock EP. Abdominal-Pelvic Lymphoproliferative Disease after Lung Transplantation: Presentation and Outcome. Transplantation. 2004; 77:431-36.

Book Chapters/Reviews

1. Driscoll, J and Chakinala MM. Treatment of Pulmonary Arterial Hypertension: Where we are and where we are going. Expert Opinion in Pharmacotherapy. 2007. (in press)

2. Sundy R and Chakinala MM. Acute Decompensated Right Ventricular Failure in the ICU. Washington University Manual of Critical Care, 1st ed.; Philadelphia: Lippincott Williams & Wilkins; 2007.

3. Yusen RD, Mayse ML, Chakinala, MM, Russell TR, and Rosenbluth DB. Pulmonary Disease. The Washington Manual of Medical Therapeutics, 32nd ed.; Philadelphia: Lippincott Williams & Wilkins; 2007.

4. Chakinala MM and Schuller DS. Pulmonary Hypertension. Washington Manual: Pulmonary Medicine Subspecialty Consult, 1st ed.; Philadelphia: Lippincott Williams & Wilkins; 2006.

5. Chakinala MM. Changing the Prognosis of Pulmonary Arterial Hypertension: Impact of Medical Therapy. Sem Respir Crit Care Medicine. 2005; 26: 409-16.

6. Chakinala MM and Trulock EP. Pneumonia in the Solid Organ Transplant Patient. Clinics in Chest Medicine. 2005; 26: 113-22.

7. Chakinala MM and Walter MJ. Community Acquired Respiratory Viral Infections after Lung Transplantation: Clinical Features and Long Term Consequences. Sem Thorac Cardiovasc Surg. 2004; 16: 342-49.

8. Chakinala MM and Trulock EP. Acute Rejection: Diagnosis and Management. Chest Surgery Clinics of North America on Lung Transplantation 2003; 13(3): 525-42.

9. Chakinala MM, Kollef M, Trulock EP. Critical Care aspects of Lung Transplant Patients. Journal of Intensive Care Medicine 2002; 17: 8-33.

10. Chakinala MM and Schuster DP. Pulmonary Edema. Fishman’s Manual of Pulmonary Diseases and Disorders, 3rd ed.; New York: McGraw-Hill; 2002.