Biographical Sketch

Research

Structural Biology; X-ray crystallography; Clathrin-mediated protein trafficking; asthma; macromolecular interactions.

Publications

1. Brett, T.J. and Traub, L.M., Molecular structures of coat and coat-associated proteins: function follows form. Current Opinion in Cell Biology, 18, 395-406 (2006).

2. Brett, T.J., Legendre-Guillemin, V., McPherson, P.S., and Fremont, D. H., Structural definition of the F-actin-binding THATCH domain from HIP1R. Nature Structural & Molecular Biology, 13, 121-130 (2006).

3. Mishra, S.K.*, Hawryluk, M.J.*, Brett, T.J.*, Keyel, P.K., Dupin, A.L., Jha, A., Heuser, J.E., Fremont, D.H., and Traub, L.M., Dual engagement regulation of protein interactions with the AP-2 adaptor ?-appendage . Journal of Biological Chemistry, 279, 46191-46203 (2004).

4. Ota, N., Brett, T.J., Murphy, T.L., Fremont, D.H., and Murphy, K.M., N-domain-dependent nonphosphorylated STAT4 dimers required for cytokine-driven activation. Nature Immunology, 5, 208-215 (2004).

5. Alexander, J.M., Nelson, C.A., van Berkel, V., Lau, E.K., Studts, J.M., Brett, T.J., Speck, S.H., Handel, T.M., Virgin, H.W., and Fremont, D.H., Structural basis of chemokine sequestration by a herpesvirus decoy receptor. Cell, 111, 343-356 (2002).

6. Brett, T.J., Traub, L.M., and Fremont, D.H., Accessory protein recruitment motifs in clathrin-mediated endocytosis . Structure (Camb), 10, 797-809 (2002).

7. Alexander, J.M., Clark, J.L., Brett, T.J., and Stezowski J.J., Chiral discrimination in cyclodextrin complexes of amino acid derivatives: ?-cyclodextrin/N-acetyl-L-phenylalanine and N-acetyl-D-phenylalanine complexes. Proceedings of the National Academy of Sciences of the U.S.A., 99, 5115-5120 (2002).

8. Mishra, S.K., Agostinelli, N.R., Brett, T.J., Mizukami, I., Ross, T.S., and Traub, L.M., Clathrin- and AP-2-binding sites in HIP1 uncover a general role for endocytic accessory proteins. Journal of Biological Chemistry, 276, 46230-46236 (2001).

Book Chapters/Reviews